JTUS, Volume 2 No. 11 November 2024 633
JTUS, Vol. 02, No. 11 November 2024
E-ISSN: 2984-7435, P-ISSN: 2984-7427
DOI: https://doi.org/10.58631/jtus.v2i11.141
Honey and cancer : A Sustainable Parallel
Relationship Especially For Developing Nations
Rehan Haider1*, Geetha Kumari Das2, Zameer Ahmed3, Sambreen Zameer4
University of Karachi, Pakistan
rehan_haider64@yahoo.com1, dasgeetha34[email protected]2,
ahmed_dr2003@yahoo.com3, sambreenz[email protected]4
Abstract
Cancer is a global fitness problem, with developing countries facing substantial challenges in
handling this sickness due to restricted entry to advanced treatment plans and economic
constraints. Honey, a natural product with diverse therapeutic residences, has proven promise
in most cancer prevention and treatment. Its bioactive compounds, along with flavonoids,
phenolic acids, and enzymes, own antioxidant, anti-inflammatory, and anti-tumorigenic homes
which could supplement conventional cancer treatments. This sustainable, value-powerful
technique is especially superb for developing countries, where access to cutting-edge therapies
remains limited. Research suggests that honey can modulate multiple molecular pathways
concerned with most cancer development, including apoptosis, cell cycle law, and angiogenesis.
It also has the potential to decrease the aspect consequences of chemotherapy and radiation,
thereby improving affected person effects. Furthermore, honey's affordability and wide
availability in many developing international locations make it a viable option to include in
integrative oncology practices. This paper explores the connection between honey and most
cancer treatments, highlighting its potential as an accessory therapy, especially in resource-
confined settings. The usage of honey gives a sustainable and handy technique, supporting
global efforts to beautify cancer care fairness. Similarly, research wants to standardize its utility,
dosage, and effectiveness in diverse cancers kinds, but the capacity of honey in cancer control
is simple, offering hope to many who face barriers to standard care.
Keywords: Antioxidant, Apoptosis, Bioactive Compounds, Developing Nations, Integrative
Oncology.
INTRODUCTION
Cancer is one of the most significant global health problems, with a growing impact in
developing countries (Wilkinson & Gathani, 2022). According to the World Health Organization
(WHO), more than 70% of cancer deaths occur in low- and middle-income countries, where limited
access to cutting-edge medical technology and adequate healthcare systems are major
Rehan Haider, Geetha Kumari Das, Zameer Ahmed, Sambreen Zameer
634 JTUS, Volume 2 No. 11 November 2024
constraints. By 2020, there are expected to be 19.3 million new cancer cases worldwide, with 10
million cancer-related deaths. Limited resources in developing countries often exacerbate the
economic, social and psychological impact experienced by cancer patients and their families.
One of the major challenges in treating cancer in developing countries is the high cost of
treatment and side effects of conventional therapies such as chemotherapy and radiation. In
addition, the prevalence of infections associated with cancer, such as hepatitis B and C viruses,
human papillomavirus (HPV), and Helicobacter pylori infection, is higher in developing countries
compared to developed countries (Chen et al., 2014). These infections contribute to a greater
burden of cancer, which could have been prevented with timely intervention.
Previous research has explored the potential of honey as an adjunctive therapeutic agent in
cancer treatment. For example, (Chan‐Zapata & Segura‐Campos, 2021) found that honey can
stimulate the production of inflammatory cytokines that aid the body's immune response to
cancer. Another study by (Masad et al., 2021) showed that flavonoids in honey have
antiproliferative effects against various types of cancer cells. A more recent study by (Ahmed &
Othman, 2017) highlighting the ability of Tualang honey to induce apoptosis in breast and cervical
cancer cells.
Although preliminary evidence supports the potential of honey as a cancer therapy, there
are still significant gaps in the literature regarding the effectiveness of honey in a broader clinical
context, particularly in developing countries. This research is important to explore the benefits of
honey in a low-cost setting, as part of a widely accessible integrative medicine approach.
This research seeks to provide new insights into how honey can be used as a sustainable
adjunctive therapy for cancer, with a particular focus on developing countries. The novelty lies in
the exploration of honey's role in the modification of molecular pathways involved in
carcinogenesis, as well as the evaluation of honey's potential to reduce the side effects of
conventional therapies.
In an effort to address the global challenges in cancer treatment, this study aims to analyze
the bioactive components in honey that contribute to anticancer activity, evaluate the
effectiveness of honey in reducing the side effects of conventional therapies such as
chemotherapy and radiation, and identify the main molecular mechanisms mediated by honey in
inhibiting cancer growth and development. With a focus on the potential of honey as a sustainable
adjunctive therapy, this study is expected to provide theoretical benefits in the form of
contributions to the scientific literature on honey as a cancer therapeutic agent. In addition, the
practical benefits include providing scientific evidence for policy makers and health practitioners
to integrate honey into cancer treatment approaches. From an economic perspective, this study
can also help reduce the cost burden of cancer care in developing countries through the use of
affordable natural therapies.
METHOD
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This research was conducted using a systematic approach involving several stages. The
study design included a literature review, case studies, and in vitro and in vivo experiments. A
literature review was conducted to analyze various scientific articles, medical research results, and
clinical trials that discussed the anticancer properties of honey and its active compounds, such as
flavonoids and phenolic acids. This study utilized various reliable sources to obtain relevant
information regarding the therapeutic benefits of honey. In addition, data was also collected
through case studies, which unearthed information on the traditional use of honey in different
regions, especially where honey has been used to treat cancer symptoms. On in vitro and in vivo
experiments, the research collected data from laboratory studies on the effects of honey on cancer
cell lines and tested the influence of honey on tumor growth using animal models. Research data
was collected through scientific databases such as PubMed and Scopus to obtain relevant peer-
reviewed articles, with a focus on sustainable and cost-effective treatment approaches. Data
analysis was conducted using statistical software to evaluate the effectiveness of honey based on
published data, as well as qualitative analysis to understand the use of honey in traditional
medicine. This approach aims to explore the potential of honey in cancer therapy holistically and
provide a comprehensive insight into the benefits of honey in the context of cancer treatment.
RESULTS AND DISCUSSION
Cancer the Gobal Epidemic
Canceris a global epidemic. In 2008, it was estimated that there were 12,332,300 cancer
cases, of which 5.4 million were in developed countries and 6.7 million had been in developing
countries (discern 1). Over half of the incident cases passed off in residents of the four World
Health Corporation (WHO) areas: AFRO (African areas), EMRO (Japanese Mediterranean region),
and SEARO (South-East Asian place), and WPRO (Western Pacific location). These are countries
with big populations with low- and center-income status (figure 2). The global population
increased from 6.1 billion in 2000 to six.7 billion in 2008. The populace growth changed into a
good deal more in growing nations than in evolved nations. Even supposing the age-specific
charges of most cancers continue to be consistent, developing nations might have a better cancer
burden than developed countries. cancer trends are showing an upward trait in many developing
nations and a mixed sample in advanced nations. With the aid of 2050, the most cancer burden
could reach 24 million instances consistent with 12 months worldwide, with 17 million instances
happening in growing international locations. Cancers that are associated with diet and lifestyle
are visible extra in evolved international locations, whilst cancers that are due to infections are
more common in growing countries. In Malaysia, dying due to cancer was ranked 1/3 (10.11%)
after coronary heart sickness (14.31%) and septicemia (16.54%) in 2005. in line with the WHO, loss
of life from cancer is anticipated to grow to 104% worldwide with the aid of 2020, the biggest
impact being in growing countries in comparison with advanced countries.
Rehan Haider, Geetha Kumari Das, Zameer Ahmed, Sambreen Zameer
636 JTUS, Volume 2 No. 11 November 2024
Figure 1. Estimated new cancer cases by
way of world regions
Figure 2. More number of cases of cancer
in growing nations in comparison with
advanced countries
While the total variety of cancer cases is increasing, the fashion of positive cancers is
changing in advanced and developing nations. In developed countries, fashion is declining
because infections by microorganisms are declining and screening facilities are available. In
Singapore, there was an average annual boom of 3.6% for breast cancers in girls from 1988 to
1992 length. In Qatar, there has been a 57.1% upward thrust of cancers from 1991 to 2006, and
inside the Netherlands, there has been a growth between 1.nine% (females) and three.4% (men)
consistent with the year for esophageal most cancers from 1989 to 2003 (Crane et al. 2007). The
cancer tendencies also are different in evolution compared with developing international
locations. The top 30 cancers of more developed (parent 12.3a) and much less developed
international locations are one of a kind, whilst cancers of the prostate, breasts, and colorectal are
more regularly occurring in evolved nations than in growing countries, the distinction is not very
apparent for cancer of the lung (discern 12.3), that is as usual in greater or less advanced
international locations. Besides breast cancers, the top 5 cancers in men and females of growing
nations are due to life or infections (DCP2 2007). On the way to understand the usefulness of
honey in cancer, we need to apprehend the different factors that might cause most cancers.
Carcinogenesis (know-how of how cancer develops) is a multistep technique and has
multifactorial causes. Improvement of cancers takes place lengthy after initiation, merchandising,
and progression steps (Figure 12.4) have taken place. The cellular damage will be via one thing or
a multiplicity of these elements. The latter is greater frequent.
1) Tobacco use, specifically cigarette smoking
2) Obesity and bodily state of no activity
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Figure 3. (a) Cancers among men visible in more developed countries. (b) Cancers
among adult males are seen in much less evolved international locations.
Figure 4. Steps in carcinogenesis. Steps altered via alcohol intake. (From Garro, A.J. et
al. Alcohol health & research global, 16(1), 8186, 1992.)
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638 JTUS, Volume 2 No. 11 November 2024
3) Diabetes, mainly kind 2
4) Infections by way of numerous microorganisms, specifically microorganisms and viruses
5) Low immune status
6) Alcohol intake
7) Chronic ulcers and wounds
Lifestyle habits/illnesses as risks to cancer improvement most cancers are caused by genetic
harm inside the genome of a cellular. This damage is both inherited or obtained during lifestyle.
The obtained genetic harm is regularly “self-inflicted” through bad life. One-0.33 of cancer is
because of tobacco use.
Figure 5. causes of most cancers. The unmarked pie segments (in descending order) are
chemical cancer agents, environmental elements, and alcohol.
The 4 main categories of cancer causes from FIGURE 5:
1) Genetic factors
2) Infectious agents
3) Lifestyle factors (including diet and tobacco)
4) Other (including chemical carcinogens, environmental factors, and alcohol)
One-1/3 because of nutritional and lifestyle elements, and one-fifth because of infections.
Other factors include chemical carcinogens, environmental pollution, and alcohol (Figure 12.5). In
growing nations, cancers as a result of infections through microorganisms, including service Cal
(by using human papillomavirus), liver (via hepatitis virus), nasopharynx (via Epstein-Barr virus),
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and stomach (by Helicobacter pylori), are more not unusual than in developed countries. These
are cancers that are theoretically preventable because infections may be eliminated with proper
treatment or vaccination, most of which can be often no longer viable or not available in many
growing countries due to a lack of monetary resources.
Smoking and Tobacco Use
Affiliation of most cancers to cigarette smoking is past doubt (Klebe et al., 2020). The
superiority of smoking is better in growing than in developed international locations. Malaysia is
a quickly developing state in Southeast Asia, with an annual GDP of $ 180 714 million, ranked
36th, in advance of neighboring international locations Singapore (ranked 43rd), Philippines
(ranked 44), and Vietnam (ranked 57th) inside the GDP list by way of the sector bank in 2007 (list
of nations using GDP [nominal] using the arena bank 2007). On the side of financial development,
Malaysia is seeing a boom in cancer instances associated with lifestyle alternatives, such as
smoking, weight problems, and diabetes (Hammond et al., 2019). in one country of Kelantan, there
has been an increment of 20.1% for 1991 to 1996 from the 1987 to 1990 duration, sixty 7.4% for
1997 to 2001 from the 1991 to 1996 length, and 143.6% for 2002 to 2007 from the 1997 to 2001
length.
Smoking is associated with some cancers which include the larynx, bladder, breast,
esophagus, and cervix. Whilst in evolved countries the prevalence of smoking is lowering, the
situation is the reverse in developing nations. In Kelantan, Malaysia, the prevalence of smoking is
15.6% amongst primary school children, 33.2% amongst secondary college youngsters, and 40.6%
among secondary college instructors. Somewhere else in different developing international
locations, children and youngsters are indulging in this awful habit (Sirichotiratana et al. 2008a,
b). Fifty-4 percent of people who smoke in Abu Dhabi started between the ages of 10 and 15
years. The initiation and the influence to begin smoking are comparable in evolved nations.
Malaysia has increased the fee for cigarettes through increasing the import taxation from RM
85/kg in 1990 to RM 216/kg in 2000; but, the rate of smoking is yet to say no, supporting the idea
proposed by way of research that growing the price of cigarettes isn't the answer to lessen
smoking. Smoking increases the threat of colorectal carcinomas by way of 43%. Ever-smokers had
been related to an 8.8-fold expanded threat of colorectal cancers (95% confidence c program
language period, 1.7forty four.9) while ate up a well-achieved crimson meat weight loss program
if they have NAT2 and CYP1A2 rapid phenotypes. No similar association change into found in in
any way smokers.
Obesity and Physical inactivity
The second critical hazards thing causing genetic damage and therefore posing a chance
for most cancers to improve is weight problems. Obese topics have about 1.5- to 3.5-fold
multiplied threat of growing cancers as compared with every day-weight topics. Weight problems
are associated with several cancers in particular endometrial, breast, and colorectal. Adipocytes
have the potential to beautify the proliferation of colon cancer cells in vitro. The fashion incidence
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640 JTUS, Volume 2 No. 11 November 2024
of overweight/weight problems is growing in lots of evolved and growing nations. In an
observation carried out in 2005 in the Kota Bharu District inside the kingdom of Kelantan, In
Malaysia, the overall occurrence of obese/obesity became 49.1%, Much higher than the figure
suggested in advance in 1996. In this community, the upward thrust of cancer is exponential in
the period between the years 2002 and 2007 (143.6% increment) in comparison with the previous
5-yr length of 1996 to 2001.
Obesity isn't always a social trouble however a disease. The finest danger is for obese
individuals who are also diabetic, especially those whose frame mass index is above 35 kg/m2.
The growth in hazard is by using 93-fold in women and 42-fold in men. obesity and physical
interest are often reciprocally related. Exercise and physical pastimes play a function in weight
from the prenatal through the adolescent time frame. In a survey of eleven, 631 high college
students in 1990, individuals who had low physical hobby tiers were additionally found to take
pleasure in many poor lives: Cigarette smoking, marijuana use, decreased fruit and vegetable
consumption, greater television watching, failure to put on a seat belt, and coffee belief of
instructional according to Performance. Individuals who had been engaged in regular physical
activity display greater appropriate health outcomes across a diffusion of physical situations
inclusive of most cancers. Smoking and bodily activities often have a reciprocal relationship.
Nonsmokers are the ones who bask in bodily sports (Lloyd & Lucas, 2014). In Taiwan, those with
lower training or income and who are younger, smokers, and chewers of betel quid exercise
significantly much less than their counterparts (Duncan, 2022). Among Shanghai Chinese, cutting-
edge people who smoke, in particular heavy people who smoke, were much less active in all sorts
of bodily activities in comparison with former smokers and nonsmokers.
Diabetes, particularly Type 2, has a risk of cancer development
Weight problems are carefully associated with diabetes (Apovian et al., 2019). A network
that has an excessive incidence of obesity additionally has an excessive incidence of diabetes. In
Kelantan, Malaysia, the superiority of diabetes in 1999 turned to 10.5% and Impaired glucose
tolerance became 16.5%. Kelantan is ranked with the highest incidence of diabetes in Malaysia
with an overall countrywide prevalence is 8.three%; accordingly, it becomes not a wonder to see
a fast rise in cancer occurrence in the country. The general occurrence of diabetes food Titus in
Kelantan in the early 1960s changed into now not recognized; however, for Malaysia, it was 0.65%.
in keeping with an overview of diabetes, the WHO has expected that, with the aid of 2030, there
will be 2.48 million diabetics in Malaysia, a leap of 164% from 0.94 million in 2002. One of the
most commonplace cancers cited in a
Community that has high diabetics and weight problems is colorectal cancer (Singh et al.,
2016). In a have a look at 138 colorectal cancers seen in the health facility Universiti Sains Malaysia,
47.8% had metabolic sicknesses, of which 13.8% were diabetes kind 2. Those diabetics with
colorectal cancers regularly have distal cancers (figure 6)
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Figure 6. Frequency of colorectal cancer cases with or without diabetes mellitus type 2 in
Hospital Universiti Sains Malaysia (20012006) by anatomic categorization.
Chronic infections at Risk of cancer Development
Several microorganisms might cause cancer. Commonplace viruses inflicting most cancers
are EpsteinBarr virus (nasopharyngeal carcinomas), human papillomavirus (cervical cancers and
different squamous cancers), and hepatitis B virus (liver cancers) (Sikdar et al., 2022). Viruses are
oncogenic after a protracted period of latency (Mesri et al., 2014). bacteria that have been studied
to have institutions with most cancers are H. pylori infections (stomach most cancers), Ureaplasma
urealyticum (prostate most cancers), and continual typhoid carrier (gallbladder most cancers).
continual fungi infections have additionally been studied to be associated with cancer. Parasites
which include Schistosoma haematobium related to carcinoma of the urinary bladder and liver
flukes Opisthorchis viverrini and Clonorchis sinensis associated with cholangiocarcinoma and
hepatocellular carcinoma. 3 principal mechanisms are using which infections can cause most
cancers, and they seem to involve initiation as well as advertising of carcinogenesis. Persistent
infection inside the host and triggered chronic inflammation are often observed by the formation
of reactive oxygen and nitrogen species. Reactive oxygen and nitrogen species have the potential
to harm DNA, proteins, and cell membranes. Continued inflammation frequently results in
repeated cycles of cell harm and compensating cell proliferation. DNA damage promotes the
increase of malignant cells. Second, infectious dealers can also at once Transform cells by putting
active oncogenes into the host genome, inhibiting tumor suppressors, or stimulating mitosis.
Third, infectious marketers, such as HIV, may additionally set off immunosuppression.
Low Immune status as Risk of cancer Development
Cancer of Aging
The maximum vital trade that might occur inside the global populace within the subsequent
50 years is the exchange in the percentage of elderly humans (>65 years): 7% in 2000 to 16% in
2050. consistent with the department of information Malaysia, the life expectancy for ladies and
men in Malaysia increases by way of 0.1 to 0.5 according to year annually seeing that 2005 (Key
information by the department of records Malaysia 2008) (Key facts with the aid of Department
of Data Malaysia 2008). Many cancers are related to growing older; although age in line with se
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isn't an essential determinant of cancer danger, it implies extended exposure to carcinogens
(Semper, 2014). By the year 2050, 27 million people are projected to have most cancers. More
than 1/2 of the expected wide variety will be citizens of growing nations. getting older is related
to decreased immune systems.
Low Immune status Due to chronic diseases
Patients who've low immune systems are at hazard for cancer development. This explains
why diabetics are greater at risk than nondiabetics to get epithelial cancers along with liver,
pancreas, breasts, and endometrium. HIV patients are vulnerable to developing epithelial and
nonepithelial cancers (Semper, 2014). Those individuals also are liable to increase in multiple
chronic infections implying the multiplicity in most cancers genesis. With autoimmune illnesses
are also prone to developing cancers inclusive colorectal carcinomas in ulcerative colitis, Crohn’s
disorder, and most cancers of the thyroid in automobile immune thyroiditis.
Continual Ulcers and wounds Persistent ulcers pose a hazard to expanding most cancers.
The most common is Marjolin’s ulcer and it's far more common in growing international locations,
particularly in rural regions with horrible living situations. This dangerous trouble is associated
with chronic infections, as maximum if no longer all chronic ulcers aren't restored because of
chronic infection.
What is HONEY?
Honey has been diagnosed for hundreds of years for its medicinal and health-selling
properties. It's far produced from a complicated enzymatic technique of nectar and saccharine
exudates accrued from several varieties of loral assets. It incorporates numerous varieties of
phytochemicals with excessive phenolic and flavonoid content fabric that contribute to its
excessive antioxidant hobby. An agent that has robust antioxidant assets may additionally have
the capability to prevent the improvement of most cancers as loose radicals and oxidative stress
play a significant position in inducing the formation of cancers. Phytochemicals available in honey
will be narrowed down into phenolic acids and polyphenols (Cianciosi et al., 2018). Versions of
polyphenols in honey were stated to have antiproliferative residences towards numerous kinds of
cancers.
Honey as a Natural Immune Booster
Honey stimulates inflammatory cytokine manufacturing from monocytes. Manuka, pasture,
and jelly bush honey had been positioned to significantly grow tumor necrosis factor-α,
interleukin-1β, and interleukin-6 release from Mono Mac 6 cells (and human monocytes) in
comparison with untreated and artificial honey-handled cells (P < zero.001. A five.8-kDa detail of
Manuka honey was positioned to stimulate cytokine production from immune cells via TLR4, an
important signaling pathway. Honey stimulates antibody production at some point of primary and
secondary immune responses toward thymus-dependent and thymus-impartial antigens in mice
injected with sheep purple blood cells and Escherichia coli antigen (Al-Waili and Haq 2004). intake
of 80 g each day of herbal honey for 21 days showed that the prostaglandin levels compared with
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normal subjects were accelerated in sufferers with AIDS. Herbal honey decreased prostaglandin
tiers and extended the NO quit product, percentage of lymphocytes, platelet rely on, and serum
protein, albumin, and copper tiers. It is probably concluded that herbal honey reduced
prostaglandin stages extended NO manufacturing, and improved hematologic and biochemical
checks in a patient with prolonged facts of AIDS. Everyday consumption of honey improves one’s
immune system.
Honey as A nAturAl Anti-inflAmmAtory Agent
In ordinary regular existence, our cells may be injured via irritants from outside or within our
body. Cell/molecular stress results in an inflammatory reaction, our frame’s defense mechanism
in seeking to do away with the irritants. In popularity, an inflammatory response to any insulting
sellers is beneficial and protective to us, but at times inflammatory responses are adverse to
fitness. Honey is a robust anti-inflammatory agent. It affords significant symptom comfort of
cough in children with a top respiratory tract infection. it has been proven to be powerful in the
manipulation of dermatitis and psoriasis vulgaris. 8 of 10 sufferers with dermatitis and five of eight
patients with psoriasis confirmed significant development after 2 weeks on a honey-primarily
based ointment. Honey at dilutions of up to 1.8 reduced bacterial adherence from 25.6 ± 6.5
(manipulate) to six.7 ± 3.3 microorganisms per epithelial cell (P < 0.001) in vitro (Alnaqdy et al.
2005). Volunteers who chewed “honey leather” showed that there had been statistically
exceptionally significant reductions in imply plaque rankings (0.90.9 reduced to 0.65 P = zero.001)
within the manuka honey group in comparison with the control institution, suggesting a capability
therapeutic position for honey in the treatment of gingivitis, periodontal ailment (English et al.
2004), mouth ulcers, and different issues of oral fitness. It has been shown in experimental mice
that honey prevents postoperative peritoneal adhesions, possibly due to speedy restoration of
surgical intraperitoneal injuries.
A case observation of a patient who had dystrophic epidermolysis bullosa who has been
dealt with many specific dressings and creams for 20 years and healed with honey impregnated
dressing in 15 weeks illustrates the usefulness of honey as an anti-inlammatory agent.
Honey As An herbal Antimicrobial
Regular, we are exposed to all kinds of microbial insults from bacteria, viruses, parasites, and
fungi. Honey is a mighty natural antimicrobial. The most unusual infection human beings get is
staphylococcal infection. The bactericidal mechanism is via disturbance in cell department
equipment. The minimum inhibitory attention for Staphylococcus aureus through Apis mellifera
honey ranged from 126.23 to 185.70 mg mL1. Honeys are also effective in coagulase-poor
staphylococci. Local application of raw honey on inflamed wounds reduced signs and symptoms
of acute inflammation, accordingly assuaging signs. The antimicrobial interest of honey is more
potent in acidic media than in impartial or alkaline media. The efficiency of honey is comparable
to a few neighborhood antibiotics. Honey's utility in infective conjunctivitis reduced redness,
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swelling, pus discharge, and time for eradication of bacterial infections. When honey is used
collectively with antibiotics, gentamicin enhances anti-S. aureus activity via 22%.
The effectiveness of honey is best when used at room temperature. Heating honey to 80°C
for 1 h reduced the antimicrobial interest of each new and saved honey. Storage of honey for five
years reduced its antimicrobial pastime, while ultraviolet mild publicity multiplied its pastime
against some microorganisms.
Honey is again active in competition to not different dermatophyte contaminations together
with ringworm of the feet vercolor (86% response), ringworm of the feet cruris (78% response),
and ringworm of the feet corporis (75% reaction)subsequently four weeks of topical spreadsheet
program serviceableness 3 instances each era and for sufferers accompanying tinea faciei
accompanying local program program application of sweet, brownish lubricate, and beeswax
aggregate.Honey additionally has happened substantiated to have antiviral houses. In an
approximate have a check, restricted serviceableness of honey evolve expected established to be
above acyclovir situation on patients accompanying recurrent herpetic lesions. Instances of labial
syphilis and individual cases of disease given through sexual relations remitted openly
accompanying utilizing dear, at the same time as no one accompanying acyclovir situation.
Honey has an antifungal impact in competition with the Candida class. Babieshurt by diaper
rash enhanced significantly afterward topical program requested analliance containing
sweetheart, brownish lubricate, and beeswax afterwards 7 days. Even assweet is made acquainted
with bacterial manner of behaviors medium, the visitor of microbial tumor onthe manner of
behaviors plates is not a possible opportunity.
Mycobacteria did not have any more tumors thus of life television holding 10% and 20%
sweet, the same time as itevolved thus of behaviors media holding five%, 2.5%, and 1% sweet,
suggesting that sweet may likewise be going to be an astonishing ant mycobacterial agent at
marvelous concentrations.
Honey is also effective in murdering tough bacterium together with Pseudomonas
aregenosa and takes care of purpose a new-epoch-day method in treating obstinate never-ending
rhino sinusitis. No matter the matter that dear is a plan to have antibacterial hometowns, the
digestive area of a Slovakian son or woman honeybee is completely inhabited by way of bacteria,
fungi, and foam. In any case not or not the closeness of bacterium in sweethas any function inside
the decontaminating effects of sweetheart is however expected examined.Continual use of honey
reduces the hazard of never-ending contaminations accompanying the beneficial aid of
microorganisms.
Honey as an Agent for ruling pressure troubles corpulent individuals are naive to increasing
most cancers. In a healing look at having 50 of something five overpressure or obese sufferers,
the managed trade activity (17 cases) obtained 70 g of hydrogeneach era for most of 30 days, and
sufferers inside the experimental activity instrumentality (38 issues)received 70 g of herbaceous
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JTUS, Volume 2 No. 11 November 2024 645
sweets at the same time. Results showed that sweet influenced nearlya moderately lessen price in
crowd burden (1.3%) and crowd fats (1.1%).
Honey As A go-between for never-ending ulcers And Wounds growing numbers of
medicine-opposing bacterium have made smooth wounds evolve expected determined and
nonhealing and as such, darling offers likelihood remedy alternatives. Honey absorbs exudates
released in wounds and devitalizedfabric. It is active in uncontrollable surgical wounds and
increases the price of improvement through the use of way of provocation of angiogenesis,
granulation, and epithelialization, making pores and pores and pores and skin grafting futile and
bestowing excellent cosmetic effects . In a randomized maneuver trial, manuka sweet progressive
wound healing in sufferers accompanying sloughy venous stage ulcers. Honey becomes
eventually proven commotion continuously accompanying methicillin-resistant S. aureus
contamination in 70% of incessantvenous ulcers. Honey is sour, and chronic nonhealinsult wounds
have an inflated salty environment. Manuka darling dressings existed and had a connection with
a statistically significant lower in wound pH.
Honey for the abilities of wound control wants the expected “controlled grade,” that is,
completely clean via γ-luminescence from the sun or another source that it may be registered as
an experimental maneuver. Available proof in meta-appraisal research implies greatly more
efficacy of honey in evaluation accompanying chance dressings for superficial or partial width
burns. Honey is a an inexpensive moist dressing accompanying uncontaminated and fabric-
recovery apartments appropriate for diabetic foot. Intralesional Darling program software
program advances recovery and leaves no scar in Urethral harms in exploratory mammals. The
not different rate of situation logical with afflicted type utilizing honey fertilizer is an extraordinary
deal oodles less expensive than unoriginal dress insult. The honey developments for wounds and
burns are inside the shape of lotion and pregnant daze or coagulate.
Honey as a herbaceous Most Cancers “Cure”
Any smooth and polyphenols determined in sweet, chiefly, caffeic acid, caffeic acidphenyl
esters, chrysin, galanin, quercetin, kaempferol, acacetin, pinocembrin, pinobanksin, and apigenin,
have progressive as promising pharmacologic dealers inside the stop and situation of most
cancers. The antioxidant avocation of Trigona carbon aria honey from Australia has evolved
expected overdone at 233.93 ± 50. 95 μMTrolox equivalents. The antioxidant avocation of 4 sweet
samples from excellent loral assets habitual overdone antioxidant families examined
accompanying the aid of the use of utilizing individual-of-a-type assay techniques. Murky sweet
had better phenolic compounds and antioxidant interest than smooth honey. The amino acid
arrangement of Darling is a sign of the toxic radical scavenging service.
Honey as a“Most Cancers Situation”
Among the one unrefined brand, honey is individual in all of the ruling class. Honey includes
several biography ins, minerals, and amino acids apart from glucose and organic compounds
composed of carbon and is correctly well-known as a healthful food (Kumar et al., 2024). There
Rehan Haider, Geetha Kumari Das, Zameer Ahmed, Sambreen Zameer
646 JTUS, Volume 2 No. 11 November 2024
are widespread styles of sweetheart (manuka sweet, grazing honey, cream shrub sweetheart, and
jungle sweet), and the types are on account of parts of the lower property. Furthermore, it has
enhanced pronounced that spoken intake of Sweetheart augments often cause illness production
in primary and subordinate invulnerable reactions in opposition to organ meat-attach and organ
meat-independent antigens normal honey prompts interleukin-6 release from Mono Mac 6
containers. Honey also exhibit antioxidant chemo preventive, antiatherogenic, immune regulatory
antimicrobial, and wound-rehabilitation homes. Honey likewise can offer the plan for the
development of novel cures for sufferers accompanying maximum cancers and maximum cancers-
associated tumors. It is examined that the wilderness full of plant and animal life sweet fragments
have chemotactic induction for neutrophils and sensitive oxygen variety, the antitumor items,
proving allure antitumor activity and reconstructing immunodeficiency. Honey has been shown
to have antineoplastic action in an exploratory bladder model in vivo and artificial.
CONCLUSION
Honey provides a promising, sustainable, and value-effective complementary method to
most cancer remedies, specifically for developing nations. Its bioactive compounds show off more
than one anticancer mechanism, and its accessibility makes it an appealing opportunity in aid-
restrained settings. At the same time as extra medical trials are needed to validate its efficacy on
a larger scale, honey’s position in most cancer control could contribute to public health and
monetary development in developing regions. Future research should focus on optimizing the
standardization of honey's bioactive compounds and their mechanisms of action to ensure
consistency in therapeutic outcomes. Additionally, large-scale clinical trials are essential to
establish dosage, safety, and efficacy across diverse populations. Exploring synergies between
honey and existing cancer treatments could further enhance its therapeutic potential. Moreover,
investigating the local production and integration of honey-based interventions into healthcare
systems could promote self-reliance and sustainable economic development in resource-
constrained settings, thereby fostering a holistic approach to cancer management in developing
nations.
BIBLIOGRAPHY
Ahmed, S., & Othman, N. H. (2017). The anti-cancer effects of Tualang honey in modulating breast
carcinogenesis: An experimental animal study. BMC Complementary and Alternative
Medicine, 17, 111.
Apovian, C. M., Okemah, J., & O’Neil, P. M. (2019). Body weight considerations in the management
of type 2 diabetes. Advances in Therapy, 36(1), 4458.
Chan‐Zapata, I., & Segura‐Campos, M. R. (2021). Honey and its protein components: effects in the
cancer immunology. Journal of Food Biochemistry, 45(5), e13613.
Chen, C.-J., Hsu, W.-L., Yang, H.-I., Lee, M.-H., Chen, H.-C., Chien, Y.-C., & You, S.-L. (2014).
Epidemiology of virus infection and human cancer. Viruses and Human Cancer: From Basic
Honey and cancer : A Sustainable Parallel Relationship Especially For Developing Nations
JTUS, Volume 2 No. 11 November 2024 647
Science to Clinical Prevention, 1132.
Cianciosi, D., Forbes-Hernández, T. Y., Afrin, S., Gasparrini, M., Reboredo-Rodriguez, P., Manna, P.
P., Zhang, J., Bravo Lamas, L., Martínez Flórez, S., & Agudo Toyos, P. (2018). Phenolic
compounds in honey and their associated health benefits: A review. Molecules, 23(9), 2322.
Duncan, S. G. (2022). Understanding Betel Quid Chewing as a Modifiable Risk Factor for Oral Cavity
Cancer.
Hammond, D., Reid, J. L., Rynard, V. L., Fong, G. T., Cummings, K. M., McNeill, A., Hitchman, S.,
Thrasher, J. F., Goniewicz, M. L., & Bansal-Travers, M. (2019). Prevalence of vaping and
smoking among adolescents in Canada, England, and the United States: repeat national
cross sectional surveys. Bmj, 365.
Klebe, S., Leigh, J., Henderson, D. W., & Nurminen, M. (2020). Asbestos, smoking and lung cancer:
an update. International Journal of Environmental Research and Public Health, 17(1), 258.
Kumar, D., Hazra, K., Prasad, P. V. V., & Bulleddu, R. (2024). Honey: an important nutrient and
adjuvant for maintenance of health and management of diseases. Journal of Ethnic Foods,
11(1), 19.
Lloyd, B., & Lucas, K. (2014). Smoking in adolescence: Images and identities. Routledge.
Masad, R. J., Haneefa, S. M., Mohamed, Y. A., Al-Sbiei, A., Bashir, G., Fernandez-Cabezudo, M. J., &
Al-Ramadi, B. K. (2021). The immunomodulatory effects of honey and associated flavonoids
in cancer. Nutrients, 13(4), 1269.
Mesri, E. A., Feitelson, M. A., & Munger, K. (2014). Human viral oncogenesis: a cancer hallmarks
analysis. Cell Host & Microbe, 15(3), 266282.
Semper, K. (2014). Risk, colon cancer & physical activity: a qualitative exploration in older adults.
University of East Anglia.
Sikdar, A., Gupta, R., & Boura, E. (2022). Reviewing Antiviral Research against Viruses Causing
Human Diseases-a Structure-Guided Approach. Current Molecular Pharmacology, 15(2),
306337.
Singh, S., Earle, C. C., Bae, S. J., Fischer, H. D., Yun, L., Austin, P. C., Rochon, P. A., Anderson, G. M.,
& Lipscombe, L. (2016). Incidence of diabetes in colorectal cancer survivors. Journal of the
National Cancer Institute, 108(6), djv402.
Wilkinson, L., & Gathani, T. (2022). Understanding breast cancer as a global health concern. The
British Journal of Radiology, 95(1130), 20211033.
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Rehan Haider, Geetha Kumari Das, Zameer Ahmed, Sambreen Zameer (2024)
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